Abortive Treatments
Drugs used to help stop individual attacks are called abortive agents or acute treatments. The pain of CH builds up so quickly and to such an excruciating peak that most drugs that are designed to be 'swallowed' do not work quickly enough.
The most effective abortive agents are those that are either administered through the lungs or nose, or by means of injection: either beneath the skin, through the muscle, or into a vein.
Triptans >
Oxygen >
Lignocaine >
Ergotamine >
Analgesics >
Others >
Triptans
The most successful abortive treatment of a cluster attack is a self-administered injection, just beneath the skin, of a drug called sumatriptan (Imigran/Imitrex). It tends to work very quickly amongst a high proportion of sufferers. In CH, unlike in migraine, injecting sumatriptan beneath the skin can be done twice a day, amongst most sufferers, without the risk of the pain reoccurring after the drug has worn off (a rebound headache).
However, sumatriptan is relatively expensive, and accordingly, many GPs and neurologists are sometimes reluctant to prescribe sufferers with this drug. It is generally felt that given the extreme nature of CH, and the excruciating pain involved, that it is unethical for this drug not to be used because of its high cost.
Sumatriptan can also be inhaled through the nose using a nasal spray, but it is much less effective than injecting beneath the skin. There is no definitive evidence that sumatriptan works for CH in tablet form. 100mg tablets taken three times daily do not prevent an attack and should not therefore be used as a preventative measure.
Zolmitriptan taken in 5mg tablet form does help the pain in some sufferers of ECH but not in CCH. However, the effectiveness is modest and isn't as effective or as fast acting as oxygen therapy (see below) or sumatriptan injected beneath the skin.
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Oxygen
Breathing in pure oxygen at a rate of between 7 to 15 litres per minute is relatively fast acting in providing pain relief amongst most sufferers. It should be inhaled continuously for 15-20 minutes using a non-breathing mask i.e. one without holes.
Sufferers of CH should use the high flow rate regulator, which now come integral to all oxygen cylinders supplied for home use in the England and Wales for CH. The low rate regulator (2-4 litres per minute) is generally unhelpful. In Scotland, sufferers of CH should use a bespoke high flow rate regulator, which unfortunately is not available on the NHS in most areas and therefore is not usually an option for sufferers who can't afford it (although we may be able to help in sourcing one).
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Lignocaine
Lignocaine in liquid form can be given as either nose drops or nasal spray, deep in the nostril on the painful side. This can bring mild to moderate relief in some sufferers though only a few experience complete pain relief. This drug, therefore, is very rarely useful on its own but can be helpful when taken with other preventative and abortive drugs.
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Ergotamine
Ergotamine used as suppositories or in tablet form is generally too slow acting to provide any meaningful pain relief.
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Analgesics
Analgesics are drugs that are used to relieve pain in normal circumstances. These include opiates - derived from the opium poppy, such as morphine etc. - and other non-steroidal anti-inflammatory drugs such as aspirin, ibuprofen, and indomethacin. None of these are effective as an abortive drug in CH attacks.
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Others
Coming soon...
